Transgender Women Involved in Strategies for Transformation (TWIST) is a peer-led, small-group, social-skills-building, and educational intervention for adult transgender women with HIV who have known their HIV status for at least three months. It consists of four 4-hour sessions, taught by two adult transgender women who are trained to deliver the intervention through attending a Training of Facilitators (TOF) course.

As an extensive adaptation of the Women Involved in Life Learning from Other Women (WILLOW) intervention, TWIST provides a framework for transgender women to share their lived experiences as a means of recognizing and valuing their social and cultural resilience. Intervention activities are guided by social cognitive theory, transgender theory, and gender affirmation theory. Intervention activities also include strategies that support gender identity and HIV-status disclosure.